Hypertension preserves the magnitude of microvascular flow-mediated dilation following transient elevation in intraluminal pressure.
William E HughesNatalya ZinkevichDavid D GuttermanAndreas M BeyerPublished in: Physiological reports (2021)
Acute exposure (30 min) to IILP (150 mmHg) attenuates the magnitude of FMD in non-CAD and CAD resistance arterioles. The presence of clinically diagnosed hypertension in non-CAD resistance arterioles preserves the magnitude of FMD following IILP as a result of a compensatory switch from NO to H2 O2 as the mechanism of dilation.