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Pharmacokinetic study of osilodrostat and identification of mono-hydroxylated metabolite in equine plasma for the purpose of doping control.

Hideaki IshiiYuhiro IshikawaFumiaki MizobeMotoi NomuraTakashi YamanakaSohei TanabeShun-Ichi NagataMasayuki YamadaGary Ngai-Wa Leung
Published in: Rapid communications in mass spectrometry : RCM (2024)
For doping control, screening of both the parent drug osilodrostat and its mono-hydroxylated metabolite in equine plasma would be recommended due to their extended detection windows of up to 2 weeks. Given the availability of reference material for potential confirmation in forensic samples, osilodrostat is considered the most appropriate monitoring target.
Keyphrases
  • loop mediated isothermal amplification
  • label free
  • climate change
  • sensitive detection