Pharmacokinetic study of osilodrostat and identification of mono-hydroxylated metabolite in equine plasma for the purpose of doping control.
Hideaki IshiiYuhiro IshikawaFumiaki MizobeMotoi NomuraTakashi YamanakaSohei TanabeShun-Ichi NagataMasayuki YamadaGary Ngai-Wa LeungPublished in: Rapid communications in mass spectrometry : RCM (2024)
For doping control, screening of both the parent drug osilodrostat and its mono-hydroxylated metabolite in equine plasma would be recommended due to their extended detection windows of up to 2 weeks. Given the availability of reference material for potential confirmation in forensic samples, osilodrostat is considered the most appropriate monitoring target.