Systematic Meta-analysis Revealed an Association of PGC-1α rs8192678 Polymorphism in Type 2 Diabetes Mellitus.

Wanning XiaNanxing ChenWenjia PengXianjie Jia Ying Yu Xuesen Wu Huaiquan Gao

Published in: Disease markers (2019)

Our development of meta-analysis revealed that the minor allele (A) carriers, especially AA genotype carriers, can lead to risk of T2DM in the Caucasian and Indian populations. This is the first report that such risk has been confirmed. Our finding shed new light into the genetic alteration in T2DM.

Keyphrases

systematic review
meta analyses
single cell
glycemic control
dna methylation
adipose tissue
genetic diversity