Significant association between host transcriptome-derived HPV oncogene E6* influence score and carcinogenic pathways, tumor size, and survival in head and neck cancer.
Tingting QinLada A KonevaYidan LiuYanxiao ZhangAnna E ArthurKatie R ZarinsThomas E CareyDouglas ChepehaGregory T WolfLaura S RozekMaureen A SartorPublished in: Head & neck (2020)
HPV E6E7 and E6* result in extensive, dose-dependent compensatory effects and dysregulation of key cancer pathways. The switch from E6 to E6* promotes oxidative phosphorylation, larger tumor size, and worse prognosis, potentially serving as a prognostic factor for HPV-positive HNSCC.