Metformin and daclatasvir: absence of a pharmacokinetic-pharmacodynamic drug interaction in healthy volunteers.
Elise Joelle SmoldersAngela ColbersClara T M M de KanterKirsten Velthoven-GraaflandLeonie T WolberinkNoor van Ewijk-Beneken KolmerJoost P H DrenthRob E AarnoutseCees J TackDavid M BurgerPublished in: British journal of clinical pharmacology (2017)
Bioequivalence analysis showed that daclatasvir does not influence the pharmacokinetics of metformin in healthy subjects. Pharmacodynamic parameters were also comparable between treatments.