Gegen-Qinlian decoction alleviates anxiety-like behaviors in methamphetamine-withdrawn mice by regulating Akkermansia and metabolism in the colon.

Xue LuYu FanYaqin PengWeichao PanDemin DuXing XuNanqin LiTeng HeJiaxun NiePengbo ShiFeifei GeDekang LiuYugen ChenXiaowei Guan

Published in: Chinese medicine (2023)

We revealed a novel effect of GQD on Meth withdrawal anxiety and identified its pharmacological target axis as "Akkermansia-Akkermansia metabolites-gut metabolites-gut microenvironment". Our findings indicated that targeting gut bacteria with TCM, such as GQD, might be a promising therapeutic strategy for addiction and related withdrawal symptoms.

Keyphrases

sleep quality
ms ms
stem cells
single cell
high fat diet induced
mouse model
physical activity
wild type