Genetic Variation in the ASTN2 Locus in Cardiovascular, Metabolic and Psychiatric Traits: Evidence for Pleiotropy Rather Than Shared Biology.
Olivia BurtKeira J A JohnstonNicholas GrahamBreda CullenDonald M LyallLaura M LyallJill P PellJoey WardDaniel J SmithRona Juliette StrawbridgePublished in: Genes (2021)
Our systematic analysis demonstrates that ASTN2 has pleiotropic effects on cardiometabolic and psychiatric traits, rather than contributing to shared pathology.