Distinct maternal metabolites are associated with obesity and glucose-insulin axis in the first trimester of pregnancy.
Julia Bandres-MerizChristina KunzJesper F HavelundNils J FærgemanAlejandro Majali-MartinezRegina EnsenauerGernot DesoyePublished in: International journal of obesity (2005) (2023)
We conclude that the metabolome of pregnant women with overweight/obesity is already altered early in pregnancy because of associated changes of C-peptide. Changes of palmitoleoyl ethanolamide concentration in pregnant women with obesity-associated hyperinsulinemia may reflect dysfunctional endocannabinoid-like signalling.