Distinct maternal metabolites are associated with obesity and glucose-insulin axis in the first trimester of pregnancy.

Julia Bandres-Meriz Christina KunzJesper F HavelundNils J FærgemanAlejandro Majali-MartinezRegina Ensenauer Gernot Desoye

Published in: International journal of obesity (2005) (2023)

We conclude that the metabolome of pregnant women with overweight/obesity is already altered early in pregnancy because of associated changes of C-peptide. Changes of palmitoleoyl ethanolamide concentration in pregnant women with obesity-associated hyperinsulinemia may reflect dysfunctional endocannabinoid-like signalling.

Keyphrases

weight loss
type diabetes
insulin resistance
weight gain
metabolic syndrome
high fat diet induced
pregnancy outcomes
pregnant women
preterm birth
birth weight
body mass index
glycemic control
physical activity
ms ms
blood glucose