Salvage of locally recurrent breast cancer with repeat breast conservation using 45 Gy hyperfractionated partial breast re-irradiation.
Ishita ChenAstrid M Botty Van den BrueleErin F GillespieBoris A MuellerAmy J XuJohn CuaronAtif J KhanBeryl McCormickOren CahlonSimon N PowellHiram CodyLior Z BraunsteinPublished in: Breast cancer research and treatment (2021)
Repeat breast conservation using the hyperfractionated partial breast RT regimen defined by RTOG 1014 (45 Gy administered in 30 1.5 Gy twice-daily fractions) appears effective and well tolerated. No grade 3 or higher toxicities were observed and local control was excellent. Longer term follow-up among larger cohorts will define whether salvage mastectomy should remain the preferred standard.