Deterioration of Regional Lung Strain and Inflammation during Early Lung Injury.

Gabriel Casulari Motta-RibeiroSoshi HashimotoTilo WinklerRebecca M BaronKira GroggLuís F S C PaulaArnoldo SantosCongli ZengKathryn HibbertRobert S HarrisEdnan BajwaMarcos F Vidal Melo

Published in: American journal of respiratory and critical care medicine (2019)

Mechanical ventilation consistent with clinical practice did not generate excessive regional strain in heterogeneously aerated supine lungs. However, it allowed worsening of spatial strain distribution in these lungs, associated with increased inflammation. Our results support the implementation of early aeration homogenization in normal lungs.

Keyphrases

mechanical ventilation
oxidative stress
clinical practice
acute respiratory distress syndrome
intensive care unit
healthcare
primary care
respiratory failure
quality improvement
extracorporeal membrane oxygenation
weight loss