Angiogenesis-Inhibitory Piperidine Alkaloids from the Leaves of Microcos paniculata .
Zhen-Long WuWei-Yan ZhangJin-Cheng ZhongXiao-Jun HuangWei XuMin-Feng ChenShao-Quan WengDong-Mei ZhangChun-Tao CheWen-Cai YeYing WangPublished in: Journal of natural products (2022)
Eight new 2,6-disubstituted piperidin-3-ol alkaloids ( 1 - 8 ), featuring a C 10 unsaturated alkyl side chain, together with three previously reported analogues ( 9 - 11 ) were isolated from the leaves of medicinal plant Microcos paniculata . Their structures and absolute configurations were elucidated unambiguously by means of 1D and 2D NMR spectroscopic data analysis, modified Mosher's method, Snatzke's method, and quantum chemical electronic circular dichroism (ECD) calculations, as well as single-crystal X-ray crystallography. The isolates were evaluated for their antiangiogenic effects on human umbilical vein endothelial cells (HUVECs). Compound 2 displayed an inhibitory effect on tube formation of HUVECs in a concentration-dependent manner.
Keyphrases
- data analysis
- endothelial cells
- high resolution
- molecular docking
- molecular dynamics
- magnetic resonance
- vascular endothelial growth factor
- solid state
- molecular dynamics simulations
- density functional theory
- high glucose
- ionic liquid
- essential oil
- monte carlo
- genetic diversity
- computed tomography
- dual energy
- energy transfer
- wound healing
- quantum dots