MRI Brain Volume Measurements in Infantile Neuronal Ceroid Lipofuscinosis.
Eva H BakerS W LevinZ ZhangAnil B MukherjeePublished in: AJNR. American journal of neuroradiology (2016)
Rapid cerebral volume loss was expected on the basis of previous qualitative reports. Because our study did not include a nontreatment arm and because progression of brain volumes in infantile neuronal ceroid lipofuscinosis has not been previously quantified, we could not determine whether our intervention had a beneficial effect on brain volumes. However, the level of quantitative detail in this study allows it to serve as a reference for evaluation of future therapeutic interventions.