Traffic on the TLR expressway.

Published in: The Journal of experimental medicine (2024)

Genetic variation in UNC93B1, a key component in TLR trafficking, can lead to autoinflammation caused by increased TLR activity. Analysis of seven patient variants combined with a comprehensive alanine screen revealed that different regions of UNC93B1 selectively regulate different TLRs (Rael et al. https://doi.org/10.1084/jem.20232005; David et al. https://doi.org/10.1084/jem.20232066).

Keyphrases

toll like receptor
inflammatory response
immune response
nuclear factor
air pollution
case report
single cell
copy number
gene expression
genome wide