Anterior Mediastinal Neuroblastoma Associated with Syndrome of Inappropriate Antidiuretic Hormone Secretion: A Morphologic, Immunohistochemical, and Genetic Case Report and Review of the Literature.
Gregory Thomas KennedyChristopher M SandeLea F SurreyFeredun S AzariCharuhas DeshpandeSunil SinghalPublished in: International journal of surgical pathology (2022)
We report a mediastinal neuroblastoma in an octogenarian with paraneoplastic syndrome of inappropriate antidiuretic hormone secretion (SIADH). Neuroblastomas are very rare tumors in adults, with thoracic or mediastinal locations being especially uncommon. These neoplasms have been occasionally associated with the SIADH. Given the rarity of incidence and paucity of diagnostic and outcomes data, the significance of standard neuroblastoma prognostic characteristics is unclear, and no treatment paradigms exist for these patients. Further studies are needed to inform future clinical guidelines.
Keyphrases
- lymph node
- end stage renal disease
- ultrasound guided
- ejection fraction
- newly diagnosed
- chronic kidney disease
- case report
- risk factors
- spinal cord
- genome wide
- peritoneal dialysis
- type diabetes
- electronic health record
- gene expression
- dna methylation
- current status
- metabolic syndrome
- combination therapy
- artificial intelligence
- patient reported
- glycemic control