Identification of a serum proteomic biomarker panel using diagnosis specific ensemble learning and symptoms for early pancreatic cancer detection.

Alexander NeyNuno R NenéEva SedlakPilar AcedoOleg BlyussHarry J WhitwellEithne CostelloAleksandra Gentry-MaharajNorman R Williams Usha MenonGiuseppe K FusaiAlexey ZaikinStephen P Pereira

Published in: PLoS computational biology (2024)

Our ensemble modelling technique outperformed CA19-9, individual biomarkers and indices developed with prevailing algorithms in distinguishing patients with non-specific but concerning symptoms from those with PDAC, with implications for improving its early detection in individuals at risk.

Keyphrases

label free
machine learning
convolutional neural network
sleep quality
deep learning
neural network
physical activity