Targeting tumor-associated macrophage-derived CD74 improves efficacy of neoadjuvant chemotherapy in combination with PD-1 blockade for cervical cancer.

Zixiang WangBingyu WangYuan FengJinwen YeZhonghao MaoTeng ZhangMeining XuWenjing ZhangXinlin JiaoQing ZhangYouzhong ZhangBaoxia Cui

Published in: Journal for immunotherapy of cancer (2024)

Our study reveals the dynamic cell-cell interaction network in the cervical cancer microenvironment influenced by combining NACT and PD-1 blockade. Furthermore, blocking tumor-associated macrophage-derived CD74 could augment neoadjuvant therapeutic efficacy.

Keyphrases

neoadjuvant chemotherapy
locally advanced
single cell
lymph node
cell therapy
adipose tissue
rectal cancer
stem cells
squamous cell carcinoma
early stage
nk cells
mesenchymal stem cells