STAT3 protects HSCs from intrinsic interferon signaling and loss of long-term blood-forming activity.

Bhakti PatelYifan ZhouRachel L BabcockFeiyang MaMalgorzata A ZalDhiraj KumarYusra B MedikLaura M KahnJosué E PinedaElizabeth M ParkXiming TangMaria Gabriela RasoTomasz ZalKaren Clise-DwyerFilippo G GiancottiSimona CollaStephanie S Watowich

Published in: bioRxiv : the preprint server for biology (2023)

STAT3 is critical for hematopoietic activity and hematopoietic stem cell maintenance in non-inflammatory conditionsSTAT3 has a cell-intrinsic role in the suppression of interferon signaling and myeloid-skewed transcription in hematopoietic stem cells.

Keyphrases

stem cells
hematopoietic stem cell
bone marrow
dendritic cells
cell proliferation
cell therapy
single cell
oxidative stress
acute myeloid leukemia
transcription factor