Comprehensive molecular characterization of lung tumors implicates AKT and MYC signaling in adenocarcinoma to squamous cell transdifferentiation.

Alvaro Quintanal-VillalongaHirokazu TaniguchiYingqian A ZhanMaysun M HasanShweta S ChavanFanli MengFathema UddinViola AllajParvathy ManojNisargbhai S ShahJoseph M ChanMetamia CiampricottiAndrew ChowMichael OffinJordana Ray-KirtonJacklynn D EggerUmesh K BhanotIrina LinkovMarina AsherMichael H RoehrlKatia VenturaJuan QiuElisa de StanchinaJason C ChangNatasha RekhtmanBrian Houck-LoomisRichard P KocheHelena A YuTriparna SenCharles M Rudin

Published in: Journal of hematology & oncology (2021)

Our findings provide the first comprehensive molecular characterization of LUSC transdifferentiation, suggesting putative drivers and potential therapeutic targets to constrain or prevent lineage plasticity.

Keyphrases

squamous cell
squamous cell carcinoma
signaling pathway
cell proliferation
transcription factor
single cell
locally advanced
human health