Skeletal muscle unloading results in increased mitophagy and decreased mitochondrial biogenesis regulation.

Pieter A LeermakersAnita E M KneppersAnnemie M W J ScholsMarco C J M KeldersChiel C de TheijeLex B VerdijkLuc J C van LoonRamon C J LangenHarry R Gosker

Published in: Muscle & nerve (2019)

These results emphasize the early-onset of skeletal muscle disuse-induced mitochondrial remodeling.

Keyphrases

skeletal muscle
early onset
oxidative stress
late onset
insulin resistance
diabetic rats
high glucose
drug induced
adipose tissue
type diabetes
nlrp inflammasome
endothelial cells