Kidney Single-cell Transcriptomes Predict Spatial Corticomedullary Gene Expression and Tissue Osmolality Gradients.
Christian HinzeNikos KaraiskosAnastasiya BoltengagenKatharina WalentinKlea RedoNina HimmerkusMarkus BleichS Steven PotterAndrew S PotterKai-Uwe EckardtChristine KocksNikolaus RajewskyKai M Schmidt-OttPublished in: Journal of the American Society of Nephrology : JASN (2020)
Single-cell transcriptomics from dissociated kidneys facilitated the prediction of spatial gene expression along the corticomedullary axis and quantitation of osmotically regulated genes, allowing the prediction of a physiologic phenotype.