Sesquiterpenoids from Chrysanthemum indicum with Inhibitory Effects on NO Production.
Jun Gu KimJin Woo LeeThi Phuong Linh LeJae Sang HanYong Beom ChoHaeun KwonDongho LeeMi-Kyeong LeeBang Yeon HwangPublished in: Journal of natural products (2021)
Three new guaianolide lactones (1-3) and four new 9-oxonerolidol glucosides (5-8) together with 20 known compounds were isolated from the MeOH extract of the flowers of Chrysanthemum indicum. Their structures were elucidated based on the interpretation of NMR, HRESIMS, and electronic circular dichroism (ECD) data along with acid hydrolysis. Of the isolates, sesquiterpenoids 1-4 and 15 and flavones 17 and 18 exhibited inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide production in RAW 264.7 cells with IC50 values in the range 0.2-27.0 μM.
Keyphrases
- lps induced
- inflammatory response
- nitric oxide
- induced apoptosis
- high resolution
- cell cycle arrest
- magnetic resonance
- oxidative stress
- electronic health record
- toll like receptor
- hydrogen peroxide
- nitric oxide synthase
- signaling pathway
- endoplasmic reticulum stress
- big data
- mass spectrometry
- cell death
- cell proliferation
- immune response
- solid state
- anaerobic digestion
- genetic diversity
- pi k akt