Neuropeptide Y regulates proliferation and apoptosis in granulosa cells in a follicular stage-dependent manner.

Yoko UrataReza SalehiPatricia D A LimaYutaka OsugaBenjamin K Tsang

Published in: Journal of ovarian research (2020)

This study is the first to evaluate the intraovarian role of NPY in granulosa cells at various stage of follicular development. These results indicate that NPY regulates granulosa cells proliferation and apoptosis in a follicular stage-dependent and autocrine manner. NPY may play a role in pathogenesis of ovarian follicular disorders.

Keyphrases

cell cycle arrest
induced apoptosis
cell death
endoplasmic reticulum stress
signaling pathway
oxidative stress
pi k akt
polycystic ovary syndrome
type diabetes
metabolic syndrome
insulin resistance