The BMP7-Derived Peptide p[63-82] Reduces Cartilage Degeneration in the Rat ACLT-pMMx Model for Posttraumatic Osteoarthritis.

Ellen G J RipmeesterJessica S J J SteijnsKarolina A P WijnandsRoderick H M J StassenVasek PitelkaLaura C W PeetersAndy CremersNzekui M S A AstrydeAlzbeta ChabronovaDon A M SurtelPieter J EmansGuus G H van den AkkerBert van RietbergenLodewijk W van RhijnMarjolein M J CaronTim J M Welting

Published in: Cartilage (2024)

Weekly intra-articular injections of p[63-82] in the rat ACLT-pMMx posttraumatic OA model resulted in reduced degenerative cartilage changes and induced functional improvement in static weightbearing capacity during follow-up.

Keyphrases

oxidative stress
extracellular matrix
mesenchymal stem cells
high glucose
drug induced