Right Ventricular Sarcomere Contractile Depression and the Role of Thick Filament Activation in Human Heart Failure With Pulmonary Hypertension.
Vivek P JaniM Imran AslamAxel J FenwickWeikang MaHenry GongGregory N MilburnDevin NissenIlton M Cubero SalazarOlivia HanselmanMonica MukherjeeMarc K HalushkaKenneth B MarguliesKenneth S CampbellThomas C IrvingDavid A KassSteven HsuPublished in: Circulation (2023)
Although there are many RV myocyte contractile deficits in HFrEF-PH, commonly used clinical indices only detect reduced isometric calcium-stimulated force, which is related to deficits in basal and recruitable %DRX myosin. Our results support use of therapies to increase %DRX and enhance length-dependent recruitment of DRX myosin heads in such patients.
Keyphrases
- heart failure
- pulmonary hypertension
- end stage renal disease
- traumatic brain injury
- skeletal muscle
- ejection fraction
- chronic kidney disease
- mycobacterium tuberculosis
- binding protein
- newly diagnosed
- depressive symptoms
- peritoneal dialysis
- left ventricular
- smooth muscle
- atrial fibrillation
- resistance training
- coronary artery
- patient reported