Clinical Outcomes in Elderly Atrial Fibrillation Patients at Increased Bleeding Risk Treated with Very-Low-Dose versus Regular-Dose Non-Vitamin K Antagonist Oral Anticoagulants: a Nationwide Cohort Study.
Yi-Hsin ChanAbigail Louise D TeShao-Wei ChenHsin-Fu LeePei-Ru LiYung-Hsin YehChi-Tai KuoLai-Chu SeeGregory Y H LipPublished in: European heart journal. Cardiovascular pharmacotherapy (2023)
Use of VLD NOACs was associated with a greater risk of arterial and venous thrombosis, death as well as the composite outcomes, when compared to that of RD NOAC in high-risk elderly AF patients at increased bleeding risk. Thromboprophylaxis with RD NOAC is still preferable over VLD NOAC for the majority of elderly AF patients at increased bleeding risk.