Pharmacokinetic interaction between regorafenib and atorvastatin in rats.
Danuta Szkutnik-FiedlerEdyta SzałekFilip OttoAndrzej CzyrskiMarta Karaźniewicz-ŁadaAnna WolcEdmund GrześkowiakKonrad LewandowskiAgnieszka KarbownikPublished in: Pharmacological reports : PR (2024)
This animal model study showed a significant pharmacokinetic interaction between regorafenib and atorvastatin. While this interaction may be clinically significant, this needs to be confirmed in clinical trials involving cancer patients.