Hypothalamic Oxytocin Neuron Activation Attenuates Intermittent Hypoxia-Induced Hypertension and Cardiac Dysfunction in an Animal Model of Sleep Apnea.
Jeannette RodriguezJoan B EscobarEmily Catherine CheungGrant KowalikRebekah RussoJhansi DyavanapalliBridget R AlberGrey HarralAman GillMakeda MelkieVivek JainKathryn Jaques SchunkeDavid MendelowitzMatthew Wyatt KayPublished in: Hypertension (Dallas, Tex. : 1979) (2023)
In animals already presenting with CIH-induced hypertension, chronic activation of hypothalamic oxytocin neurons blunted the progression of hypertension and conferred cardioprotection after an additional 4 weeks of CIH exposure. These results have significant clinical translation for the treatment of cardiovascular disease in patients with obstructive sleep apnea.