Brain Distribution of Dual ABCB1/ABCG2 Substrates Is Unaltered in a Beta-Amyloidosis Mouse Model.
Thomas WanekViktoria ZoufalMirjam BrackhanMarkus KrohnSeverin MairingerThomas FilipMichael SaubererJohann StanekThomas PekarJens PahnkeOliver LangerPublished in: International journal of molecular sciences (2020)
Despite a reduction in the abundance of cerebral ABCG2 and ABCB1 in APP/PS1-21 mice, the brain distribution of two dual ABCB1/ABCG2 substrates was unaltered. Our results suggest that the brain distribution of clinically used ABCB1/ABCG2 substrate drugs may not differ between AD patients and healthy people.
Keyphrases
- resting state
- white matter
- mouse model
- end stage renal disease
- cerebral ischemia
- functional connectivity
- newly diagnosed
- cancer stem cells
- ejection fraction
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- subarachnoid hemorrhage
- metabolic syndrome
- brain injury
- wastewater treatment
- antibiotic resistance genes