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Multi-Organ Transcriptome Dynamics in a Mouse Model of Cecal Ligation and Puncture-Induced Polymicrobial Sepsis.

Izabela RumienczykMaria KuleckaJerzy OstrowskiDaniel MarKarol BomsztykStephen W StandageMichal Mikula
Published in: Journal of inflammation research (2021)
RNA sequencing across organs and time-points in the CLP murine model allowed us to study the trajectories of transcriptome changes demonstrating alterations common across multiple organs as well as biological pathways altered in an organ-specific manner. These findings could pave new directions in the research of sepsis-induced MODS and indicate new sepsis treatment strategies.
Keyphrases
  • single cell
  • acute kidney injury
  • septic shock
  • intensive care unit
  • mouse model
  • high glucose
  • rna seq
  • diabetic rats
  • gene expression
  • genome wide
  • drug induced
  • oxidative stress
  • dna methylation