Prognostic significance of postoperative serological incomplete conversion of AFP and PIVKA-II after hepatic resection for hepatocellular carcinoma: a multicenter analysis of 1755 patients.
Mingda WangGuojun QianHongmei XiaoXingkai LiuLiyang SunZhong ChenKongying LinLanqing YaoChao LiLihui GuJiahao XuXiaodong SunWei QiuTimothy M PawlikWan Yee LauGuoyue LvFeng ShenFeng ShenPublished in: The oncologist (2024)
The results emphasize that postoperative incomplete conversion of either AFP or PIVKA-II is a significant prognostic marker, indicating a higher risk for adverse oncologic outcomes following HCC resection. This revelation has crucial implications for refining postoperative adjuvant therapy and surveillance strategies for HCC patients.