A randomized phase I trial of nanoparticle albumin-bound paclitaxel with or without mifepristone for advanced breast cancer.

Rita NandaErica M Stringer-ReasorPoornima SahaMasha KocherginskyJean GibsonBernadette LibaoPhilip C HoffmanElias ObeidDouglas E MerkelGalina KhramtsovaMaxwell SkorThomas KrauszRonald N CohenMark J RatainGini F FlemingSuzanne D Conzen

Published in: SpringerPlus (2016)

GR appears to be a promising target in TNBC, and GR inhibition plus chemotherapy produces manageable toxicity. While neutropenia was observed in some, a nab-paclitaxel dose of 100 mg/m(2) plus mifepristone 300 mg was found to be tolerable, and a randomized phase II trial of nab-paclitaxel with/without mifepristone is planned in GR-positive advanced TNBC.

Keyphrases

chemotherapy induced
advanced non small cell lung cancer
clinical trial
study protocol
oxidative stress
locally advanced
phase iii
phase ii
radiation therapy