Heritable anisotropy associated with cognitive impairments among patients with schizophrenia and their non-psychotic relatives in multiplex families.

Konasale M PrasadJ GertlerS TollefsonJ A WoodD RoalfR C GurR E GurL AlmasyM F Pogue-GeileV L Nimgaonkar

Published in: Psychological medicine (2020)

Our data show significant heritability of all three-types of tracts among relatives of schizophrenia. Significant heritability of FA of multiple tracts was not entirely due to genetic correlations among the tracts. Diagnostic group main effect and correlation with neurocognitive performance were mainly restricted to tracts with heritable FA suggesting shared genetic effects on these traits.

Keyphrases

bipolar disorder
genome wide
copy number
high throughput
big data
gene expression
machine learning
deep learning