Vaccination Shapes Within-Host SARS-CoV-2 Diversity of Omicron BA.2.2 Breakthrough Infection.

Yi ZhangYang ZhouJiazhen ChenJing WuXun WangYumeng ZhangShiyong WangPeng CuiYuanyuan XuYang LiZhongliang ShenTao XuQiran ZhangJianpeng CaiHaocheng ZhangPengfei WangJingwen AiNing JiangChao QiuWenhong Zhang

Published in: The Journal of infectious diseases (2023)

In SARS-CoV-2 infections, vaccine-induced immunity was associated with decreased diversity of within-host variant spectra, with milder inflammatory pathophysiology. The enrichment of mutations in the spike protein gene indicates selection pressure exerted by vaccination on the evolution of SARS-CoV-2.

Keyphrases

sars cov
respiratory syndrome coronavirus
high glucose
oxidative stress
diabetic rats
genome wide
copy number
gene expression
drug induced
transcription factor
dna methylation
coronavirus disease
endothelial cells