A pangenome graph reference of 30 chicken genomes allows genotyping of large and complex structural variants.

Edward S RiceAntton AlberdiJames AlfieriGiridhar AthreyJennifer R BalaccoPhilippe BardouHeath BlackmonMathieu CharlesHans H ChengOlivier FedrigoSteven R FiddamanGiulio FormentiLaurent A F FrantzM Thomas P GilbertCari J HearnErich D JarvisChristophe KloppSofia MarcosAndrew S MasonDeborah Velez-IrizarryLuohao XuWesley C Warren

Published in: BMC biology (2023)

We expect that this new paradigm of genomic reference will allow better pinpointing of exact mutations responsible for specific phenotypes, which will in turn be necessary for breeding chickens that meet new sustainability criteria and are resilient to quickly evolving pathogen threats.

Keyphrases

copy number
genome wide
high throughput
heat stress
fluorescent probe
density functional theory
sensitive detection
living cells
candida albicans
gene expression
dna methylation
machine learning
genetic diversity
deep learning
molecular dynamics
single molecule
disease virus