Zoanthamine Alkaloids from the Zoantharian Zoanthus cf. pulchellus and Their Effects in Neuroinflammation.
Paul O GuillenSandra GegundeKarla B JaramilloAmparo AlfonsoKevin CalabroEva AlonsoJenny RodriguezLuis M BotanaOlivier P ThomasPublished in: Marine drugs (2018)
Two new zoanthamine alkaloids, namely 3-acetoxynorzoanthamine (1) and 3-acetoxyzoanthamine (2), have been isolated from the zoantharian Zoanthus cf. pulchellus collected off the coast of the Santa Elena Peninsula, Ecuador, together with three known derivatives: zoanthamine, norzoanthamine, and 3-hydroxynorzoanthamine. The chemical structures of 1 and 2 were determined by interpretation of their 1D and 2D NMR data and comparison with literature data. This is the first report of zoanthamine-type alkaloids from Zoanthus cf. pulchellus collected in the Tropical Eastern Pacific. The neuroinflammatory activity of all the isolated compounds was evaluated in microglia BV-2 cells and high inhibitory effects were observed in reactive oxygen species (ROS) and nitric oxide (NO) generation.
Keyphrases
- cystic fibrosis
- reactive oxygen species
- nitric oxide
- electronic health record
- lipopolysaccharide induced
- induced apoptosis
- high resolution
- lps induced
- big data
- systematic review
- inflammatory response
- magnetic resonance
- traumatic brain injury
- cell cycle arrest
- cell death
- climate change
- hydrogen peroxide
- neuropathic pain
- data analysis
- nitric oxide synthase
- cerebral ischemia
- spinal cord
- mass spectrometry
- machine learning
- pi k akt
- clinical evaluation