The molecular and gene/miRNA expression profiles of radioiodine resistant papillary thyroid cancer.
Laura FugazzolaEmanuela MinnaChiara GargiuliMarina MuzzaMatteo DugoLoris De CeccoGabriele PogliaghiDelfina TosiGaetano BulfamanteAngela GrecoLaura FugazzolaMaria Grazia BorrelloPublished in: Journal of experimental & clinical cancer research : CR (2020)
The present data indicate a different molecular profile in RAI-avid and RAI-refractory metastatic PTCs. Moreover, BRAFV600E tumors displayed reduced differentiation and intrinsic RAI refractoriness, while PTCs with fusion oncogenes are RAI-avid but persistent, suggesting different oncogene-driven mechanisms leading to RAI refractoriness.