Expansion and activation of distinct central memory T lymphocyte subsets in complex regional pain syndrome.
Marc A RussoNathan T FioreCaryn van VredenDominic BaileyDanielle M SantarelliHelen M McGuireBarbara Fazekas de St GrothPaul J AustinPublished in: Journal of neuroinflammation (2019)
These findings represent the first mass cytometry immunophenotyping study in any chronic pain state and provide preliminary evidence of an antigen-mediated T lymphocyte response in CRPS. In particular, the presence of increased numbers of long-lived central memory CD4+ and CD8+ T lymphocytes with increased activation of pro-inflammatory signalling pathways may indicate ongoing inflammation and cellular damage in CRPS.