Neurofibromatosis type 1 (Nf1)-mutant mice exhibit increased sleep fragmentation.
Corina AnastasakiNicholas RensingKevin J JohnsonMichael WongDavid H GutmannPublished in: Journal of sleep research (2019)
Neurofibromatosis type 1 (NF1) is a neurodevelopmental disorder in which affected children and adults are at a higher risk of sleep disorders. In an effort to identify potential sleep disturbances in a small animal model, we used a previously reported Nf1 conditional knockout (Nf1CKO ) mouse strain. In contrast to Nf1 mutant flies, the distribution of vigilance states was intact in Nf1CKO mice. However, Nf1CKO mice exhibited increased non-REM sleep (NREM)-to-wake and wake-to-NREM transitions. This sleep disruption was accompanied by decreased bout durations during awake and NREM sleep states under both light and dark conditions. Moreover, Nf1CKO mice have higher percentage delta power during awake and NREM sleep states under all light conditions. Taken together, Nf1CKO mice phenocopy some of the sleep disturbances observed in NF1 patients and provide a tractable platform to explore the molecular mechanisms governing sleep abnormalities in NF1.
Keyphrases
- signaling pathway
- lps induced
- pi k akt
- nuclear factor
- sleep quality
- oxidative stress
- physical activity
- inflammatory response
- wild type
- type diabetes
- chronic kidney disease
- computed tomography
- end stage renal disease
- magnetic resonance imaging
- toll like receptor
- cell proliferation
- immune response
- risk assessment
- climate change