Single-cell transcriptomes and chromatin accessibility of endothelial cells unravel transcription factors associated with dysregulated angiogenesis in systemic sclerosis.

Mengqi HuangTracy TabibDinesh KhannaShervin Assassi Robyn T DomsicRobert Lafyatis

Published in: Annals of the rheumatic diseases (2024)

This study unveils transcriptional and chromatin alterations in driving endovascular dysregulation in SSc, proposing ELK4, ERF and ETS1 as novel targets in ECs for addressing vascular complications in the condition.

Keyphrases

transcription factor
systemic sclerosis
endothelial cells
single cell
interstitial lung disease
gene expression
rna seq
dna damage
vascular endothelial growth factor
high glucose
high throughput
genome wide
rheumatoid arthritis
dna methylation
aortic dissection