Anti-mutant efficacy of antibiotic combinations: in vitro model studies with linezolid and daptomycin.
Stephen H ZinnerKamilla N AlievaMaria V GolikovaElena N StrukovaYury A PortnoyAlexander A FirsovPublished in: The Journal of antimicrobial chemotherapy (2021)
The present study suggests that (i) the inhibition of S. aureus resistant mutants using linezolid/daptomycin combinations can be predicted by MPCs determined at pharmacokinetically derived antibiotic concentration ratios and (ii) T>MPC is a reliable predictor of the anti-mutant efficacy of antibiotic combinations as studied using in vitro dynamic models.