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NETosis Drives Blood Pressure Elevation and Vascular Dysfunction in Hypertension.

Jaya KrishnanElizabeth M HennenMingfang AoAnnet KiraboTaseer AhmadNéstor de la VisitaciónDavid M Patrick
Published in: Circulation research (2024)
These observations identify a role of NETosis in the pathogenesis of hypertension. Moreover, they define an important role of EC stretch and TRPV4 as initiators of NETosis. Finally, they define a role of citrullinated histones as drivers of EC dysfunction in hypertension.
Keyphrases
  • blood pressure
  • hypertensive patients
  • heart rate
  • oxidative stress
  • blood glucose
  • type diabetes
  • adipose tissue