Genetic variations in toll-like receptors 7 and 8 modulate natural hepatitis C outcomes and liver disease progression.

Fatima-Zohra FakhirMustapha LkhiderWafaa BadreRhimou AlaouiEliane F Meurs Pascal PineauSayeh EzzikouriSoumaya Benjelloun

Published in: Liver international : official journal of the International Association for the Study of the Liver (2017)

Our results suggest that variations in TLR7 and TLR8 genes modulate the clearance and progression of HCV infection with different magnitudes between sexes. Our results refine, therefore, our understanding of the sex-specific differences observed regarding the susceptibility to chronic hepatitis.

Keyphrases

toll like receptor
inflammatory response
genome wide
immune response
hepatitis c virus
nuclear factor
human immunodeficiency virus
copy number
type diabetes
gene expression
transcription factor