Sildenafil reduces neuroinflammation in cerebellum, restores GABAergic tone, and improves motor in-coordination in rats with hepatic encephalopathy.

Ana AgustiVicente Hernández-RabazaTiziano BalzanoLucas Taoro-GonzalezAndrea Ibañez-GrauAndrea Cabrera-PastorSantos FusteroMarta LlansolaCarmina MontoliuVicente Felipo

Published in: CNS neuroscience & therapeutics (2017)

This study supports an interplay between cGMP-neuroinflammation and GABAergic neurotransmission in impairing motor coordination in PCS rats.

Keyphrases

traumatic brain injury
lipopolysaccharide induced
lps induced
cognitive impairment
nitric oxide
cerebral ischemia
early onset
pulmonary arterial hypertension
protein kinase
brain injury
subarachnoid hemorrhage