Sildenafil reduces neuroinflammation in cerebellum, restores GABAergic tone, and improves motor in-coordination in rats with hepatic encephalopathy.

Ana AgustiVicente Hernández-RabazaTiziano BalzanoLucas Taoro-GonzalezAndrea Ibañez-GrauAndrea Cabrera-PastorSantos FusteroMarta LlansolaCarmina MontoliuVicente Felipo
Published in: CNS neuroscience & therapeutics (2017)
This study supports an interplay between cGMP-neuroinflammation and GABAergic neurotransmission in impairing motor coordination in PCS rats.