α-Synucleinopathy associated c-Abl activation causes p53-dependent autophagy impairment.

Md Razaul KarimElly E LiaoJaekwang KimJoyce MeintsHector Martell MartinezOlga PletnikovaJuan C TroncosoMichael K Lee

Published in: Molecular neurodegeneration (2020)

Collectively, our data show that c-Abl activation by α-synucleinopathy causes p53 dependent autophagy deficits and both c-Abl and p53 represent therapeutic target for PD.

Keyphrases

tyrosine kinase
chronic myeloid leukemia
cell death
endoplasmic reticulum stress
signaling pathway
oxidative stress
traumatic brain injury
electronic health record
big data
deep learning
data analysis