Evaluation of dose-dependent treatment effects after mid-trial dose escalation in biomarker, clinical, and cognitive outcomes for gantenerumab or solanezumab in dominantly inherited Alzheimer's disease.
Guoqiao WangYan LiChengjie XiongEric McDadeDavid B CliffordSusan L MillsAnna M SantacruzAndrew J AschenbrennerJason HassenstabTammie L S BenzingerBrian A GordonAnne M FaganKelley A CoalierJorge J Libre-GuerraAustin McCulloughNelly Joseph-MathurinCharles D ChenCatherine MummeryBarbara A WendelbergerSerge GauthierMario MasellisKaren C HoldridgeRoy YaariSaptarshi ChatterjeeJohn SimsPaul DelmarGeoffrey A KerchnerTobias BittnerCarsten HofmannRandall J Batemannull nullPublished in: Alzheimer's & dementia (Amsterdam, Netherlands) (2022)
We evaluated the dose-dependent treatment effect of two different amyloid-specific immunotherapies.Dose-dependent treatment effects were observed in some biomarkers.No dose-dependent treatment effects were observed in clinical/cognitive outcomes, potentially due to the fact that the modified study may not have been powered to detect such treatment effects in symptomatic subjects at a mild stage of disease exposed to high (or maximal) doses of medication for prolonged durations.