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CD19-specific CAR T Cells that Express a PD-1/CD28 Chimeric Switch-Receptor are Effective in Patients with PD-L1-positive B-Cell Lymphoma.

Hui LiuWen LeiChaoting ZhangChunmei YangJuying WeiQunyi GuoXiaojun GuoZhilu ChenYing LuKen H YoungZheming LuWenbin Qian
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
This first-in-human study demonstrates the tolerability, safety, and encouraging efficacy of CD19-PD-1/CD28-CART in PD-L1+ large B-cell lymphoma.
Keyphrases
  • diffuse large b cell lymphoma
  • nk cells
  • induced apoptosis
  • open label
  • oxidative stress
  • signaling pathway
  • cell cycle arrest
  • endoplasmic reticulum stress