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Age-related dysregulation of CXCL9/10 in monocytes is linked to impaired innate immune responses in a mouse model of Staphylococcus aureus osteomyelitis.

Yihuang LinMankai YangChubin ChengJichang WuBin YuXianrong Zhang
Published in: Cellular and molecular life sciences : CMLS (2024)
These findings demonstrate that bone marrow monocytes act as a critical promotor of innate immune response via the CXLCL9/10-CXCR3 axis upon S. aureus infection, and that the increased susceptibility to S. aureus infection in skeleton in an aged host may be largely attributable to the declined induction of CXCR9/10 in monocytes.
Keyphrases
  • immune response
  • dendritic cells
  • innate immune
  • bone marrow
  • staphylococcus aureus
  • mouse model
  • peripheral blood
  • mesenchymal stem cells
  • cell migration
  • toll like receptor
  • biofilm formation