The tumor suppressor FOXO3a mediates the response to EGFR inhibition in glioblastoma cells.

Guillem RamisRuth Villalonga-PlanellsMargalida Serra-SitjarMarta BrellSilvia Fernández de MattosPriam Villalonga

Published in: Cellular oncology (Dordrecht) (2019)

Our data indicate that FOXO3a activation is a crucial event in the response of GBM cells to EGFR inhibition, suggesting that FOXO3a may serve as an actionable therapeutic target that can be modulated using FDA-approved drugs.

Keyphrases

induced apoptosis
cell cycle arrest
signaling pathway
small cell lung cancer
transcription factor
pi k akt
epidermal growth factor receptor
tyrosine kinase
machine learning
big data
data analysis
drug administration