chiro-Inositol Derivatives from Chisocheton paniculatus Showing Inhibition of Nitric Oxide Production.
Khan Viet NguyenDuc Viet HoHien Minh NguyenThao Thi DoKiem Van PhanHiroyuki MoritaJyrki HeinämäkiAin RaalHoai Thi NguyenPublished in: Journal of natural products (2020)
Six new chiro-inositol derivatives (1-6) were isolated from the leaves of Chisocheton paniculatus collected in Vietnam. Their chemical structures were elucidated by 1D and 2D NMR and HRESIMS analyses. All isolated compounds were evaluated for their inhibitory activity against lipopolysaccharide-induced nitric oxide (NO) production in the RAW 264.7 macrophage cell line. Compound 4 exhibited potent inhibitory activity for NO production with an IC50 value of 7.1 μM.