[18F]FDG PET signal is driven by astroglial glutamate transport.
Eduardo R ZimmerMaxime J ParentDébora G SouzaAntoine LeuzyClotilde LecruxHyoung-Ihl KimSerge GauthierLuc PellerinEdith HamelPedro Rosa-NetoPublished in: Nature neuroscience (2017)
Contributions of glial cells to neuroenergetics have been the focus of extensive debate. Here we provide positron emission tomography evidence that activation of astrocytic glutamate transport via the excitatory amino acid transporter GLT-1 triggers widespread but graded glucose uptake in the rodent brain. Our results highlight the need for a reevaluation of the interpretation of [18F]FDG positron emission tomography data, whereby astrocytes would be recognized as contributing to the [18F]FDG signal.
Keyphrases
- positron emission tomography
- computed tomography
- pet ct
- pet imaging
- amino acid
- induced apoptosis
- cell cycle arrest
- white matter
- electronic health record
- resting state
- oxidative stress
- big data
- blood glucose
- multiple sclerosis
- neuropathic pain
- cell proliferation
- signaling pathway
- spinal cord
- spinal cord injury
- skeletal muscle
- cerebral ischemia